Dimethyl Sulfoxide → HCID 57293194, compound

Participants

Reaction Conditions

Reaction Steps

A mixture comprising 5.0 g of 1-{4-(2,2,2-trifluoroethoxy)phenylvinyl}-2-nitroiminoimidazolidine, 5.8 g of 2-chloro-5-chloromethylpyridine, 8.4 g of potassium carbonate and 30 ml of dimethylsulfoxide was stirred at 60° C. for one hour. The reaction mixture was poured into water, extracted with ethyl acetate, washed with water, dried (with anhydrous MgSO4) and concentrated to give an oily residue. This was purified by column chromatography (silica gel, eluent: ethyl acetate/hexane=4/1) to give 4.9 g of 1-(2-chloropyridin-5-ylmethyl)-2-nitroimino-3-{4-(2,2,2-trifluoroethoxy)phenylvinyl}-imidazolidine.

Provenance & Evidence