Sodium Hydroxide → HCID 10988662, compound

Participants

Reaction Steps

Methyl ester 3 (8 g) was dissolved in methanol (200 ml) containing sodium hydroxide (10 g), and the reaction mixture was stirred at r.t. (room temperature) for 2 h. The solvent was evaporated, the residue rendered acidic with 3N HCl, then extracted with ethyl acetate, the extract dried (MgSO4) and evaporated, to give colorless crystals of 1,3-dimethyl-5-methoxyoxindole-3-acetic acid (4, 7.1 g, 94%) of m.p. 120°-121° degrees C.

Provenance & Evidence