HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 3-(2-Nitroethenyl)thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 3-Thiophenecarboxaldehyde | HCID 68135 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 3-(2-Nitroethenyl)thiophene | HCID 2732418 | 56% |
Reaction Steps
When R2 is H the thiophene-3-carboxaldehyde (1 eq) was dissolved in 2-propanol and treated with nitromethane (1 eq), benzylamine (0.065 eq) and glacial acetic acid (0.13 eq). After 60 minutes of refluxing, the mixture was cooled, the solid was collected and washed with ice-cold ether to afford the product (56%); mp 94.5°-96.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05310941 |
| Source dataset | uspto-grants-1994_05 |
| ORD ID | ord-0ec95865eb6a47d8b36470c4c605d77d |
| Source note | uspto-grants-1994_05 |