HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1033601Generated: October 31, 2026
Potassium Carbonate → 5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole
https://huagongshe.com/reaction/1033601
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 5-(4'-hydroxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole | HCID 10074472 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole | HCID 10370839 | — |
Reaction Steps
To a mixture of 5-(4'-hydroxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole (0.01 m=4.90 g) and potassium carbonate (0.05 m=6.90 g) stirred in 50 mL N,N-dimethylacetamide chilled at 1° C. was added a total of 3.34 g (0.024 m) of methanesulfonyl chloride in 0 portions over 6 hours. The progress of the reaction was monitored by thin layer chromatography or HPLC. The title compound was formed in better than 90% in the mixture which was used in the next example.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05310928 |
|---|
| Source dataset | uspto-grants-1994_05 |
|---|
| ORD ID | ord-ec5354c8117b47c788af1b9b71ec3f89 |
|---|
| Source note | uspto-grants-1994_05 |
|---|
