Dimethylformamide → HCID 15228888, compound

Participants

Reaction Steps

1.32 g of 4-ethyl-2-propyl-1-[[2'-(N-triphenylmethyl(tetrazol-5-yl))biphenyl-4-yl]methyl]imidazole-5-carboxylic acid, 0.39 mL of iodopropane and 0.55 g potassium carbonate were added to 6 mL DMF. The reaction was allowed to stir for 24 hours then diluted with 12 mL water and 90 mL ethyl acetate. The organic layer was separated and washed five times with water, once with brine and dried with MgSO4. Chromatography with a gradient from 5 to 50% ethyl acetate in hexane gave 0.96 g of desired product.

Provenance & Evidence