Acetic Acid → HCID 178440060, compound

HRID 1033610Notes

Reaction equation

HRID 1033610 reaction equation
[CH2:1]([C:3]1[N:4]=[C:5]([CH2:55][CH2:56][CH3:57])[N:6]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]3[N:35](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:34]=[N:33][N:32]=3)=[CH:21][CH:20]=2)[C:7]=1[C:8]([O:10][CH2:11][O:12][C:13](=[O:17])[CH:14]([CH3:16])[CH3:15])=[O:9])[CH3:2].C(O)(=O)C>CO>[CH2:1]([C:3]1[N:4]=[C:5]([CH2:55][CH2:56][CH3:57])[N:6]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]3[NH:32][N:33]=[N:34][N:35]=3)=[CH:21][CH:20]=2)[C:7]=1[C:8]([O:10][CH2:11][O:12][C:13](=[O:17])[CH:14]([CH3:15])[CH3:16])=[O:9])[CH3:2]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 19026352HCID 19026352, compound

Product 1

HCID 178440060HCID 178440060, compoundYield 79.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 0.46 g isobutyryloxymethyl 4-ethyl-2-propyl-1-[[2'-(N-triphenylmethyl(tetrazol-5-yl))biphenyl-4-yl]methyl]imidazole-5-carboxylate in 10 mL MeOH was added 1 5 mL glacial acetic acid and the mixture stirred 2 days at room temperature. The reaction was evaporated to near dryness and the residue purified by flash chromatography using a 0% to 5% MeOH/CHCl3 gradient. There was obtained 0.250 g of the title compound.

Workup

  1. customThe reaction was evaporated
  2. customthe residue purified by flash chromatography

Sources & evidence

ORD record
ord-f5e512eaa4eb4355a1186776e260ee1c
Source dataset
uspto-grants-1994_05
Patent number
US05310929

Reaction notes

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