Ammonium Chloride → HCID 15341843, compound

HRID 1033657Notes

Reaction equation

HRID 1033657 reaction equation
[CH:1]1([CH2:4][C:5]2[C:6]([OH:16])=[C:7]([CH:12]=[CH:13][C:14]=2[OH:15])[C:8](OC)=[O:9])[CH2:3][CH2:2]1.[Cl-].[NH4+:18]>>[CH:1]1([CH2:4][C:5]2[C:6]([OH:16])=[C:7]([CH:12]=[CH:13][C:14]=2[OH:15])[C:8]([NH2:18])=[O:9])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 25517Ammonium ChlorideHCID 15341799HCID 15341799, compound

Product 1

HCID 15341843HCID 15341843, compound

Procedure

The compound of Example 15 is heated at 50° C. in a saturated ammonium chloride solution overnight. The reaction mixture is thoroughly extracted with ethyl acetate, and the solvent dried (Na2SO4) and evaporated in vacuo to afford the crude product. Chromatographic purification or silica gel using ethyl acetate/hexane (4:6) as eluant affords the product.

Workup

  1. extractionThe reaction mixture is thoroughly extracted with ethyl acetate
  2. dry with materialthe solvent dried (Na2SO4)
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-c5a247d36daf45d3b8519925f5849b6b
Source dataset
uspto-grants-1994_05
Patent number
US05310951

Reaction notes

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