HCID 14722828, compound → HCID 22399592, compound

HRID 1033658Notes

Reaction equation

HRID 1033658 reaction equation
[CH:1]1([CH2:4][C:5]2[C:6]([OH:15])=[C:7]([CH:11]=[CH:12][C:13]=2[OH:14])[C:8]([NH2:10])=[O:9])[CH2:3][CH2:2]1.I[CH2:17][CH2:18][CH2:19][O:20][C:21]1[CH:34]=[CH:33][C:24]2[CH2:25][CH2:26][CH:27]([C:29]([O:31][CH3:32])=[O:30])[O:28][C:23]=2[C:22]=1[CH2:35][CH2:36][CH3:37]>>[NH2:10][C:8]([C:7]1[CH:11]=[CH:12][C:13]([O:14][CH2:17][CH2:18][CH2:19][O:20][C:21]2[CH:34]=[CH:33][C:24]3[CH:25]=[CH:26][CH:27]([C:29]([O:31][CH3:32])=[O:30])[O:28][C:23]=3[C:22]=2[CH2:35][CH2:36][CH3:37])=[C:5]([CH2:4][CH:1]2[CH2:3][CH2:2]2)[C:6]=1[OH:15])=[O:9]

Participants

3

Reactant 2

HCID 14722828HCID 14722828, compoundHCID 15341843HCID 15341843, compound

Product 1

HCID 22399592HCID 22399592, compound

Procedure

The compound of Example 66 and the compound of Example 23 are reacted together under the conditions described in Example 24. The crude product is purified by chromatography on silica gel using ethyl acetate/hexane (4:6) as eluant to afford the product.

Workup

  1. customThe crude product is purified by chromatography on silica gel
  2. customto afford the product

Sources & evidence

ORD record
ord-7eb969b88ebb49178a8446f4fbe2b04e
Source dataset
uspto-grants-1994_05
Patent number
US05310951

Reaction notes

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