Trifluoroacetic acid → HCID 86747839, compound

Participants

Reaction Steps

288 mg of (2S,4S)-2-[4-(2-hydroxyethyl)piperazinylcarbonyl]-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)pyrrolidine (prepared as described in Preparation 7) were dissolved in 560 μl of anisole, and the solution was placed on an ice bath. 2.8 ml of trifluoroacetic acid and 91 μl of trifluoromethanesulfonic acid were added to the solution, still on the ice bath, and the resulting mixture was stirred for 1 hour at room temperature. At the end of this time, the solvent was removed by distillation under reduced pressure. The resulting residue was washed with diethyl ether by repeated decantation, and then dried under reduced pressure, to give 380 mg of the title compound.

Provenance & Evidence