Trifluoroacetic acid → HCID 22851534, compound

Participants

Reaction Steps

2.7 ml of trifluoroacetic acid and 88 μl of trifluoromethanesulfonic acid were added, whilst ice-cooling, to a solution of 308 mg of (2S,4S)-4-(4-methoxybenzylthio)-2-[4-(2-carbamoyloxyethyl) -1-homopiperazinylcarbonyl]-1-(4-nitrobenzyloxycarbonyl)pyrrolidine dissolved in 543 μl of anisole, and the resulting mixture was stirred a the same temperature for 1 hour. At the end of this time, the reaction mixture was worked up in a similar manner to that described in Example 32(1), to afford 315 mg of the title compound.

Provenance & Evidence