1,4-Dibromobutane → HCID 19024280, compound

Participants

Reaction Steps

A solution of 200 mg of 1,3,4,5-tetrahydro-2-benzazepine-1,3-dione dissolved in 20 ml of dimethylformamide was ice-cooled, and then 0.209 ml (1.5 equivalents) of 1,4-dibromobutane, 54.8 mg (1.2 equivalents) of 60% sodium hydride were added, followed by stirring under ice-cooling for 1.5 hours. The reaction treatment and purification were conducted in the same manner as in Example 13, to obtain 213 mg of the desired compound (yield 60%).

Provenance & Evidence