反应详情

6.3 g (30 mmol) of ethyl 5-methyl-2,3,4,5,6,7-hexahydro-1H-pyrrolo[3,4-c)pyridine-2 -carboxylate and 18.9 g (60 mmol) of Ba(OH)2. 8H2O are refluxed for 15 hours in 75 ml of water. After cooling, the BaCO3 is filtered off with suction, the filtrate is concentrated, and the residue is extracted by boiling five times with 50 ml portions of dioxane. The dioxane solutions are concentrated, and the residue is distilled.

1. temperatureAfter cooling
2. filtrationthe BaCO3 is filtered off with suction
3. concentrationthe filtrate is concentrated
4. extractionthe residue is extracted
5. concentrationThe dioxane solutions are concentrated
6. distillationthe residue is distilled