HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1033769Generated: October 30, 2026
Triethyl phosphite → Triethyl 2-fluoro-2-phosphonoacetate
https://huagongshe.com/reaction/1033769
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethyl phosphite | HCID 31215 | — |
| Reactant | Acetic acid, 2-bromo-2-fluoro-, ethyl ester | HCID 2733407 | — |
| Product | Triethyl 2-fluoro-2-phosphonoacetate | HCID 2734865 | 77.4% |
Reaction Steps
A mixture of 4.00 g (24.0 mmol) of triethyl phosphite and 4.45 g (24.0 mmol) of ethyl bromofluoroacetate (purchased from PCR Inc. Gainesville, Fla.) was heated to 150° C. for 4 h under argon. The contents of the flask were cooled to RT and then distilled under vacuum (0.5 mm Hg) to provide 4.5 g (77%) of title compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05312814 |
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| Source dataset | uspto-grants-1994_05 |
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| ORD ID | ord-3480beea78234d27a7bca3e804442db1 |
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| Source note | uspto-grants-1994_05 |
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