Trifluoroacetic acid → HCID 19024447, compound

Participants

Reaction Steps

A solution of 59 mg (0.11 mmole) of 1-[N-[[2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl]-N-pentylcarbamoyl]indoline (from Step A), 20 μL of anisole, and 0.5 mL of anhydrous TFA was stirred at room temperature for 16 hours. The residue obtained after evaporation of excess TFA was flash chromatographed over silica gel (elution with 0.5% MeOH--CH2Cl2) to give 49 mg (89%) of the title compound as a hard gum, homogeneous by TLC (95:5 MeOH--CH2Cl2); FAB-MS m/e 478 (M+1)+.

Provenance & Evidence