Trifluoroacetic acid → HCID 19024426, compound

Participants

Reaction Steps

A solution of 86 mg (0.16 mmole) of 1-[N-[[2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl]-N-pentylcarbamoyl]-1,2,3,4-tetrahydroquinoline (from Step A), 30 μL of anisole, and 0.8 mL of anhydrous TFA was stirred at room temperature for 16 hours. The residue obtained after evaporation of excess TFA was flash chromatographed over silica gel (elution with 0.5% MeOH in CH2Cl2) to give 55 mg (71%) of the title compound as an off-white foam, homogeneous by TLC (95:5 MeOHCH2Cl2), FAB-MS m/e 492 (M+1)+.

Provenance & Evidence