2-Chlorobenzoic Acid → HCID 19024450, compound

Participants

Reaction Steps

The title compound was prepared from 2-chlorobenzoic acid (2.0 equivalents), CDI (2.0 equiv), 1-[N-pentyl-N-[(2'-sulfamoylbiphenyl-4-yl)methyl]carbamoyl]-1,2,3,4-tetrahydroquinoline (from Step B) (1.0 equiv), and DBU (2.0 equiv), according to the procedure of Example 3, Step C, to give a 78% yield of the desired material after flash chromatography as an off-white solid, mp 71°-74° C.; homogeneous by TLC in 9:1 CH2Cl2 --MeOH; FAB-MS m/e 630 (M+1)+.

Provenance & Evidence