1,2,3,4-Tetrahydroquinoline → HCID 19024473, compound

Participants

Reaction Steps

The title compound was prepared from N-butyl-N-[[2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl]carbamoyl chloride (from Example 4, Step A), N,N-diisopropylethylamine, and 1,2,3,4-tetrahydroquinoline in toluene, according to the procedure of Example 4, Step A, to give 93% yield of the desired material after flash chromatography as a foam, homogeneous by TLC in 4:1 hexane-EtOAc; FAB-MS m/e 534 (M+1)+.

Provenance & Evidence