2-Chlorobenzoic Acid → HCID 19024437, compound

Participants

Reaction Steps

The title compound was prepared from 2-chlorobenzoic acid (2.5 equivalents), CDI (2.5 equiv), 1-[N-butyl-N-[(2'-sulfamoylbiphenyl-4-yl)methyl]carbamoyl]-1,2,3,4-tetrahydroquinoline (from Step B) (1.0 equiv), and DBU (2.5 equiv), according to the procedure of Example 3, Step C, to give an 83% of the desired material after flash chromatography as an off-white solid, mp 80°-82° C.; homogeneous by TLC in 95:5 CH2Cl2 --MeOH; FAB-MS m/e 616 (M+1)+.

Provenance & Evidence