2-Chlorobenzoic Acid → HCID 19024433, compound

Participants

Reaction Steps

Following the procedure of Example 1, Step I, 1-butyl-3-methyl-1-[(2'-sulfamoylbiphenyl-4-yl)methyl]-3-[2-(trifluoromethyl)phenyl]urea was acylated with 2-chlorobenzoic acid. After work-up, the crude product was purified initially by flash chromatography on silica gel (elution with 2% and then 5% MeOH in CH2Cl2). Further purification by HPLC on a Zorbax C8 Semiprep reversed phase column (70:30 MeCN--H2O, containing 0.1% TFA) provided a 29% yield of the title compound as a stiff, white foam, mp>60° C. (gradual); homogeneous by TLC (95:5 CH2Cl2 --MeOH); FAB-MS m/e 658 (M+1)+.

Provenance & Evidence