Acetic Acid → HCID 178446309, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 29.3 mg (0.405 mmole) of 1-[N-pentyl-N-[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]carbamoyl]-1,2,3,4-tetrahydroquinoline (from Step E), 400 μL of glacial acetic acid, and 180 μL of H2O was stirred under N2 at 60° C. for 16 hours, then cooled, and concentrated to dryness in vacuo. The residual oil was flash chromatographed on silica gel (elution with 3% and then 5% MeOH in CH2Cl2) to yield 6.0 mg (31%) of the title compound as a stiff foam, homogeneous by TLC (95:5 CH2Cl2 --MeOH); FAB-MS m/e 481 (M+1)+.

Provenance & Evidence