Hydrochloric Acid → HCID 19024930, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of N-(2-benzylthio-2-methylpropyl)-N-(2-dimethylphosphinothioylethyl)methoxyacetamide (750 mg) in dry toluene (10 cm3) at 0° C., under an atmosphere of dry nitrogen was added a solution of boranetetrahydrofuran complex in tetrahydrofuran (5.25 cm3, 1M). The mixture was stirred for 30 min at 0° C. and then for 4 h at room temperature. Concentrated hydrochloric acid (1 cm3) was added carefully and the tetrahydrofuran then removed under reduced pressure. The remaining aqueous solution was made strongly basic by the addition of aqueous sodium hydroxide (6M) and then extracted with chloroform (3×10 cm3). The extracts were dried (Na2SO4) and the solvent removed to give the product (500 mg, 71%) as a yellow oil.

Provenance & Evidence