Sodium Hydroxide → HCID 19024940, compound

HRID 1033827Notes

Reaction equation

HRID 1033827 reaction equation
Br[CH2:2][C:3]([OH:10])([CH2:7][O:8][CH3:9])[CH2:4][O:5][CH3:6].[OH-].[Na+]>O>[CH3:6][O:5][CH2:4][C:3]1([CH2:7][O:8][CH3:9])[CH2:2][O:10]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10727299HCID 10727299, compound

Product 1

HCID 19024940HCID 19024940, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 1-bromo-2-hydroxy-3-methoxy-2-(methoxymethyl)propane (30 g) was added sodium hydroxide (5.6 g) in water (50 cm3). The mixture was stirred at room temperature for 1 h and then extracted with diethyl ether. The extracts were dried (Na2SO4) and the solvent removed under reduced pressure (40° C. at 15 mmHg) to give the oxirane (13 g, 70%) as a colourless liquid. No further purification of this material was needed.

Workup

  1. extractionextracted with diethyl ether
  2. dry with materialThe extracts were dried (Na2SO4)
  3. customthe solvent removed under reduced pressure (40° C. at 15 mmHg)

Sources & evidence

ORD record
ord-23a0cba623e847b2a7a6f6d71fb83d92
Source dataset
uspto-grants-1994_05
Patent number
US05312904

Reaction notes

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