HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1033838Generated: November 1, 2026
2-Methylbenzenesulfonic acid hydrate → (R)-2-acetamido-3-ethoxycarbonyl-2-penten-4-olide
https://huagongshe.com/reaction/1033838
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Methylbenzenesulfonic acid hydrate | HCID 12496995 | — |
| Reactant | (R)-2-amino-3-ethoxycarbonyl-2-penten-4-olide | HCID 22851708 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | (R)-2-acetamido-3-ethoxycarbonyl-2-penten-4-olide | HCID 22851706 | — |
Reaction Steps
12.04 g of (R)-2-amino-3-ethoxycarbonyl-2-penten-4-olide are dissolved in 48 ml of acetic anhydride, 125 mg of toluenesulphonic acid monohydrate are added and the whole is stirred overnight at 40° C. The mixture is concentrated by evaporation, dissolved in ethyl acetate and washed with water. The ethyl acetate is distilled off and the residue is recrystallised from ethyl acetate/cyclohexane, [α]D20 =+62.3° (3% in CHCl3), m.p. 119°-122° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05312914 |
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| Source dataset | uspto-grants-1994_05 |
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| ORD ID | ord-523f0648441e4a9ab422680dbd6ca173 |
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| Source note | uspto-grants-1994_05 |
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