Acetic Acid Mixture with Hydrobromic Acid → HCID 57210532, compound

Participants

Reaction Steps

A mixture of 2.2 g of 4-benzyloxycarbonyl-5-{2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)-(L)-phenylalanyl]aminoethyl}thiazole and 30 ml of a 25% hydrogen bromide-acetic acid solution was stirred at room temperature for one day. After removing the solvent, the mixture was neutralized with a 10% potassium carbonate aqueous solution. The crystals obtained were recrystallized from a methanol-isopropyl ether mixed solution to obtain 1.27 g of 4-carboxy-5-{2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)-(L)-phenylalanyl]aminoethyl}thiazole.

Provenance & Evidence