Sodium Hydroxide → HCID 67849091, compound

Participants

Reaction Steps

A solution of ethyl (E)-4-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2,2-bis(benzyl)-3-butenoate (121 mg) in ethanol (5 mL) was heated to reflux with 10% sodium hydroxide solution (3 mL) for 2 hours. The ethanol was evaporated, water was added and the aqueous layer was extracted with ether. The water layer was acidified to pH 1 with dilute hydrochloric acid solution, extracted with ethyl acetate, dried and concentrated to a solid. Trituration with ether provided 75 mg of the white solid hydrochloride salt of the title compound; mp 184°-185° C.

Provenance & Evidence