Sodium Hydroxide → HCID 10002389, compound

Participants

Reaction Steps

A solution of ethyl (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-benzyl-2-butenoate (623 mg, 1.38 mmol) in ethanol (25 mL) under argon was treated with 10% sodium hydroxide solution (20 mL), and then stirred for 1 hour at room temperature. An additional 25 mL of 10% sodium hydroxide were added and the mixture was stirred overnight at ambient temperature. Acidification to pH 4 with dilute hydrochloric acid solution followed by extraction with methylene chloride and washing with water gave after drying and workup, 630 mg of crude product. Trituration with ethyl acetate/ether provided the title compound (302 mg, 52%), mp 206°-207° C., as the white hydrochloride salt.

Provenance & Evidence