HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (E)-3-[2-n-Butyl-1-{(4-carbomethoxyphenyl)methyl}-1H-imidazol-5-yl]-2-benzyl-2-propenoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Methyl 4-[(2-butyl-5-formyl-1H-imidazol-1-YL)methyl]benzoate | HCID 10334966 | — |
| Reactant | Benzenepropanoic acid, 1,1-dimethylethyl ester | HCID 10878309 | — |
| Reactant | 2-n-Butyl-1-(4-carboethoxy-2-chlorobenzyl)imidazole-5-aldehyde | HCID 19936789 | — |
| Product | (E)-3-[2-n-Butyl-1-{(4-carbomethoxyphenyl)methyl}-1H-imidazol-5-yl]-2-benzyl-2-propenoic Acid | HCID 67849095 | — |
Reaction Steps
The title compound was prepared using 2-n-butyl-1-[(4-carbomethoxyphenyl)methyl]imidazole-5-aldehyde, prepared by the method described for the preparation of 2-n-butyl-1-[(4-carboethoxy-2-chlorophenyl)methyl]imidazole-5-aldehyde in Example 44, and t-butyl 3-phenylpropanoate by the procedure of Example 27, except, instead of basic hydrolysis, trifluoroacetic acid hydrolysis of the t-butyl ester is employed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05312828 |
| Source dataset | uspto-grants-1994_05 |
| ORD ID | ord-5d1cc15cf6e944c9be305b34a6e2c374 |
| Source note | uspto-grants-1994_05 |