HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-phenylpropionate → (E)-3-[2-n-Butyl-1-{(4-cyanophenyl)methyl}-1H-imidazol-5-yl]-2-benzyl-2-propenoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-phenylpropionate | HCID 7643 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-n-Butyl-1-(4-carboethoxy-2-chlorobenzyl)imidazole-5-aldehyde | HCID 19936789 | — |
| Reactant | HCID 178441598 | HCID 178441598 | — |
| Product | (E)-3-[2-n-Butyl-1-{(4-cyanophenyl)methyl}-1H-imidazol-5-yl]-2-benzyl-2-propenoic Acid | HCID 67849253 | — |
Reaction Steps
The title compound is prepared by the procedure of Example 27, using 2-n-butyl-[(4-cyanophenyl)methyl]imidazole-5-aldehyde, prepared by the method of Example 42 describing the preparation of 2-n-butyl-1-[(4-carboethoxy-2-chlorophenyl)methyl]imidazole-5-aldehyde, and methyl 3-phenylpropanoate, except, instead of basic hydrolysis of the ester with sodium hydroxide, potassium carbonate hydrolysis was employed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05312828 |
| Source dataset | uspto-grants-1994_05 |
| ORD ID | ord-61c99a7af3bf48ddb3906d89c099ac76 |
| Source note | uspto-grants-1994_05 |