HCID 54045152, compound → HCID 54511231, compound

HRID 1033931Notes

Reaction equation

HRID 1033931 reaction equation
[CH2:1]([O:3][C:4](=[O:34])[CH:5]([CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[N:6]1[CH:10]=[C:9]([NH:11][C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-])=O)[C:15]=2[C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:13])[N:8]=[CH:7]1)[CH3:2]>[Pd]>[CH2:1]([O:3][C:4](=[O:34])[CH:5]([CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[N:6]1[CH:10]=[C:9]([NH:11][C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([NH2:20])[C:15]=2[C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:13])[N:8]=[CH:7]1)[CH3:2]

Participants

3

Reactant 1

HCID 54045152HCID 54045152, compound

Product 1

HCID 54511231HCID 54511231, compoundYield 98.4%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of 5.1 g of a-hexyl-4-{[(3-nitro-2-ethoxycarbonylphenyl)carbonyl]amino}imidazole-1-acetic acid ethyl ester and 2.1 g of 5% palladium-on-carbon were hydrogenated in the presence of 150 ml of methanol until consumption of hydrogen ceased. The catalyst was removed by filtration and the filtrate concentrated in vacuo to provide 4.7 g of the desired subtitled intermediate. NMR.

Workup

  1. customwere hydrogenated in the presence of 150 ml of methanol until consumption of hydrogen
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-616074f5cbce46af80e0c8756914d200
Source dataset
uspto-grants-1994_05
Patent number
US05312936

Reaction notes

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