Sodium Methoxide → HCID 19025023, compound

Participants

Reaction Steps

325.5 g (1.07 mol) of ethyl 2-[N-(2-oxopropyl)phenylacetylamino]isobutyrate was dissolved in 1.5 l of ethanol, and 77 g (1.28 mol) of 90% sodium methylate powder was added thereto. The mixture was refluxed under heating for 30 minutes. Ethanol was distilled off, and the residue was poured into ice water. Precipitated crystals were collected by filtration. The crystals were thoroughly washed with hexane and dried to obtain 73 g (yield: 24%) of the desired product having a melting point of from 64 to 66° C.

Provenance & Evidence