HCID 67822243, compound → HCID 67822079, compound

Participants

Reaction Steps

A solution of 2-benzylamino-7-(ethoxycarbonylpropan-3-yloxy) tetralin hydrochloride (14 g), prepared as described in Example 3, in a mixture of 95% ethanol (250 ml) and water (10 ml) is hydrogenated at atmospheric pressure and 60° C. in the presence of 10% Pd/C (2 g) as the hydrogenation catalyst. After 5 hours the catalyst is filtered off, the filtrate is concentrated to dryness and the residue is taken up in absolute ethanol (100 ml) and concentrated to dryness a few times. The obtained product is then triturated with acetone, filtered and crystallized from isopropanol affording 8.8 g of the compound of the title. M.p. 134°-136° C.

Provenance & Evidence