Water → HCID 67822213, compound

Participants

Reaction Steps

A solution of 2-benzylamino-7-(ethoxycarbonylbutan-4-yloxy)tetralin hydrochloride (10.7 g), prepared as described in Example 5, in 95% ethanol (250 ml) and water (25 ml) is hydrogenated at 60° C. and atmospheric pressure using 10% Pd/C (1.2 g) as the hydrogenation catalyst. After 6 hours the catalyst is filtered off, the filtrate is concentrated and the residue is taken up in absolute ethanol and concentrated to dryness a few times. The obtained product is then triturated with ethyl ether and filtered. The residue is crystallized from isopropanol yielding 8 g of the compound indicated in the title. M.p. 131°-133° C.

Provenance & Evidence