Hydrochloric Acid → HCID 86747864, compound

Participants

Reaction Steps

10 ml of methanol and 0.724 g of sodium methylate were mixed together under an inert gas atmosphere and 4 g of the product of Step A of Example 12 in 30 ml of methanol were added slowly at 0°,+5° C. The mixture was stirred for 16 hours at about +5° C. and was poured into a mixture of water and ice to which 15 ml of 2N hydrochloric acid had been added. After stirring for 15 minutes, extraction was carried out with methylene chloride. The organic phase was washed with water, dried and evaporated to dryness. The residue was chromatographed on silica, eluting with a methylene chloride - cyclohexane mixture (1-1) to obtain 0.879 g of the expected product.

Provenance & Evidence