2-Oxopropanoyl chloride → N-(1,2-Dioxopropyl)-L-alanine trimethylsilyl ester
Reaction equation
[C:1](Cl)(=[O:5])[C:2]([CH3:4])=[O:3].Cl.[CH3:8][Si:9]([O:12][C:13](=[O:17])[C@H:14]([CH3:16])[NH2:15])([CH3:11])[CH3:10]>>[CH3:8][Si:9]([O:12][C:13](=[O:17])[C@H:14]([CH3:16])[NH:15][C:1](=[O:5])[C:2]([CH3:4])=[O:3])([CH3:11])[CH3:10]Participants
3
Procedure
A method of synthesizing pyruvyl-alanine or pyruvyl-glycine according to the invention comprises the steps of reacting sodium pyruvate with oxalyl chloride to yield pyruvyl chloride, then reacting pyruvyl chloride with a suspension of alanine trimethylsilyl ester hydrochloride to yield a pyruvyl-alanine trimethylsilyl ester and then subjecting the pyruvyl-alanine trimethylsilyl estertohydrolysis to yield pyruvyl-alanine. The pyruvyl-alanine synthesized via the method set forth above serves as a pyruvyl-amino acid pyruvate precursor.
Sources & evidence
- ORD record
- ord-b9bb1c7e8fe64d749f5cb72d44983d7e
- Source dataset
- uspto-grants-1994_05
- Patent number
- US05312985
Reaction notes
Loading…