2-Oxopropanoyl chloride → HCID 86747334, compound

HRID 1033969Notes

Reaction equation

HRID 1033969 reaction equation
[C:1](Cl)(=[O:5])[C:2]([CH3:4])=[O:3].Cl.[CH3:8][Si:9]([O:12][C:13](=[O:19])[C@H:14]([CH:16]([CH3:18])[CH3:17])[NH2:15])([CH3:11])[CH3:10]>>[CH3:11][Si:9]([O:12][C:13](=[O:19])[C@H:14]([CH:16]([CH3:17])[CH3:18])[NH:15][C:1](=[O:5])[C:2]([CH3:4])=[O:3])([CH3:8])[CH3:10]

Participants

3

Reactant 2

HCID 5217912-Oxopropanoyl chlorideHCID 86747335HCID 86747335, compound

Product 1

HCID 86747334HCID 86747334, compound

Procedure

A method of synthesizing pyruvyl-valine according to the invention comprises the steps of reacting sodium pyruvate with oxalyl chloride to yield pyruvyl chloride, then reacting the pyruvyl chloride with a suspension of valine trimethylsilyl ester hydrochloride to yield pyruvyl-valine trimethylsilyl ester and then subjecting the pyruvyl-valine trimethylsilyl ester to hydrolysis to yield pyruvyl-valine. The pyruvyl-valine synthesized via the route set forth above serves as a pyruvyl-amino acid pyruvate precursor.

Sources & evidence

ORD record
ord-6396648dc5fc48eba739ff7852fc56ec
Source dataset
uspto-grants-1994_05
Patent number
US05312985

Reaction notes

Loading…