Methanol → 3-Methyl-1-(2-piperidinophenyl)-1-butylamine, (S)-

HRID 1034028Notes

Reaction equation

HRID 1034028 reaction equation
[CH3:1][CH:2]([CH3:18])[CH2:3][CH:4]([NH2:17])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.CO>CC(C)=O>[CH3:1][CH:2]([CH3:18])[CH2:3][C@H:4]([NH2:17])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 887MethanolHCID 104220523-Methyl-1-(2-piperidino-phenyl)-1-butylamine

Product 1

HCID 105146093-Methyl-1-(2-piperidinophenyl)-1-butylamine, (S)-

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Equimolar quantities of racemic 3-methyl-1-(2-pieridinophenyl)-1-butylamine and of N-acetyl-L-gluatmic acid were refluxed in aceton, whereby methanol was added in such an amount to yield a clear solution.

Workup

  1. customto yield a clear solution

Sources & evidence

ORD record
ord-c7c9878917d64b64ae694f6a86695de4
Source dataset
uspto-grants-1994_05
Patent number
US05312924

Reaction notes

Loading…