HCID 9859463, compound → HCID 9964391, compound

Participants

Reaction Steps

To a solution of 3.1 g of 2,3-difluoro-6-nitro-{[(R)-2-hydroxypropyl]oxy}benzene (VIIIR, Xa=Xb=F) in 50 ml of ethanol was added 500 mg of 5% palladium on charcoal. Catalytic reduction was performed under atmospheric pressure at room temperature. When the absorption of hydrogen ceased, the catalyst was removed by filtration and the solvent was removed from the filtrate under reduced pressure. The residue was purified through silica gel column chromatography to yield 2.47 g of the titled compound.

Provenance & Evidence