Hydrochloric Acid → HCID 19024822, compound

Participants

Reaction Conditions

Reaction Steps

1N aqueous solution of sodium hydroxide (6 ml) was added to a solution of methyl 3-[1-(3-isobutylphenyl ) ethoxy]benzoate (1.40 g ) in a mixture of 1.4-dioxane (12 ml ) and methanol (6 ml ) . The reaction mixture was stirred at 25° C. for 18 hours, and then poured into a mixture of ether and 1N hydrochloric acid. The organic layer was separated, washed with water and brine, dried over magnesium sulfate, and evaporated. The crystalline residue was washed with hexane to give 3-[1-(3-isobutylphenyl ) ethoxy]benzoic acid (1.20 g) as colorless crystals.

Provenance & Evidence