反应详情

温度

80 °C

60 g of 2,6-difluoroaniline was dissolved in 180 ml of acetic acid. A solution containing 75 g of iodine chloride dissolved in 48 ml of acetic acid was added dropwise therein, and then agitated at 80° C. for 2 hours. The reaction solution was poured into water, and the resulting deposited crystals were filtrated and washed with water. The crystals were recrystallized with methanol, vacuum distilled (125° C./22 mmHg), and recrystallized again with methanol to obtain 57 g of 2,6-difluoro-4-iodoaniline.

1. additionwas added dropwise
2. filtrationwere filtrated
3. washwashed with water
4. customThe crystals were recrystallized with methanol, vacuum
5. distillationdistilled (125° C./22 mmHg)
6. customrecrystallized again with methanol