Homophthalic anhydride → HCID 13365959, compound

HRID 1034149Notes

Reaction equation

HRID 1034149 reaction equation
[C:1]1(=[O:12])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[CH2:4][C:3](=[O:11])O1.[NH2:13][CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][N:21]([C:24]2[N:29]=[CH:28][CH:27]=[CH:26][N:25]=2)[CH2:20][CH2:19]1>C(Cl)Cl>[N:25]1[CH:26]=[CH:27][CH:28]=[N:29][C:24]=1[N:21]1[CH2:22][CH2:23][N:18]([CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[C:3](=[O:11])[CH2:4][C:5]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:1]2=[O:12])[CH2:19][CH2:20]1

Participants

4

Reactant 2

HCID 12801Homophthalic anhydrideHCID 128407054-(2-Pyrimidinyl)-1-piperazinebutanamine

Product 1

HCID 13365959HCID 13365959, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.02 mol of 2-benzopyran-1,3(4H)dione and 0.02 mol of 1-(4-aminobutyl)-4-(2-pyrimidinyl)piperazine are heated at 160°-170° C. for 1 hours under an atmosphere of N2, with stirring. The mixture is then allowed to cool and the substance is dissolved in methylene chloride. The substance is purified over a silica gel column (mobile phase: CH2Cl2 /iprOH (10:0.5)).

Workup

  1. temperatureto cool
  2. customThe substance is purified over a silica gel column (mobile phase: CH2Cl2 /iprOH (10:0.5))

Sources & evidence

ORD record
ord-af64c02d98fd488fab8108e2eeabf62b
Source dataset
uspto-grants-1994_05
Patent number
US05314884

Reaction notes

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