関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1,3-Dibromopropane | HCID 8001 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | 7-Methoxy-2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide | HCID 12528490 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(3-bromopropyl)-7-methoxy-1,2,4-benzothiadiazin-3(4H)one 1,1-dioxide | HCID 19023431 | — |
反応手順
0.03 mol of 7-methoxy-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide is dissolved in 50 ml of absolute DMF, and 0.03 mol of sodium hydride is added. After 15 minutes, formation of the sodium salt was complete. Then 0.06 mol of 1,3-dibromopropane is added dropwise and the mixture is heated at 80° C. for 2 hours. The solvent is then distilled out and the residue is purified by column chromatography on silica gel. The eluting agent used was a mixture of CH2Cl2CH3OH (98:2).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05314884 |
|---|
| 出典データセット | uspto-grants-1994_05 |
|---|
| ORD ID | ord-03ff218ef33e4ad7a99ae3f2e7a7d6ef |
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| 出典メモ | uspto-grants-1994_05 |
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