Dimethyl Sulfoxide → HCID 19023627, compound

Participants

Reaction Steps

2.8 g of 2-[(4-chlorobutyl)sulfonyl]benzyl alcohol was treated with 1.4 ml of oxalyl chloride, 2.4 ml of dimethylsulfoxide, and 7.8 ml of triethylamine in the same manner as described for Example 1, Part B. Purification of the crude product via column chromatography on silica gel, eluting with 60:10:30 toluene:ethyl acetate:hexane provided 2.45 g of the product. 1H-NMR (CDCl3) δ 1.91-1.97(m,4H); 3.35(t,2H,J=7 Hz); 3.54(t,2H,J=6 Hz); 7.80-7.85(m,2H); 8.07-8.14(m,2H); 10.75(s,1H). Mass spectrum: 261 (M+H).

Provenance & Evidence