Sodium Iodide → HCID 14970438, compound

Participants

Reaction Steps

0.89 g of 2-amino-1,4-dihydro-4-{2-[(4-chlorobutyl)sulfonyl]phenyl}-6-methyl-5-nitro-3-pyridinecarboxylic acid methyl ester was treated with 0.60 g of sodium iodide, 0.34 g of sodium bicarbonate and 0.42 g of 2-methoxyphenyl-1-piperazine in 25 ml of DMF using the procedure as described for Example 3. Purification via column chromatography on silica gel, eluting with 60:35:5 toluene:ethyl acetate:methanol gave 0.10 g of product, m.p. 145°-147° C. 1H-NMR (d6 -DMSO) δ 1.57-1.63(m,2H); 1.80-1.87(m,2H); 2.36(t,2H,J=7 Hz); 2.45(s,3H); 2.49(s,4H); 2.94(s,4H); 3.35(m,2H); 3.40(s,3H); 3.77(s,3H); 6.50(s,1H); 6.88-6.92(m,6H); 7.35-7.81(m,4H); 9.50(br s,1H). Mass spectrum: 600 (M+H).

Provenance & Evidence