Methyl iodide → (E)-2,2,2-trifluoro-N-methoxy-1-(1-methylpyridin-1-ium-3-yl)ethanimine iodide

Participants

Reaction Steps

E-3-(α,α,α-Trifluoroacetyl)pyridine-O-methyl oxime (D7) (6.16 g, 0.030 mol) was treated with methyl iodide (15 ml, 0.241 mol) in acetonitrile (100 ml) at reflux for 3 h. The reaction mixture was cooled and evaporated to give a gum which was triturated with ether to give the title compound (D10) as a yellow solid (10.44 g, 100%) m.p. 119°-124° C.

Provenance & Evidence