HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1034212Generated: November 2, 2026
1-Chloro-4-(chloromethyl)benzene → 1-(4-Chlorophenylmethyl)-2-aminobenzimidazole
https://huagongshe.com/reaction/1034212
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Chloro-4-(chloromethyl)benzene | HCID 7723 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Aminobenzimidazole | HCID 13624 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(4-Chlorophenylmethyl)-2-aminobenzimidazole | HCID 743900 | — |
Reaction Steps
A mixture of 2-amino benzimidazole (6.66 g, 50 mmol), 4-chlorobenzylchloride (8.86 g, 55 mmol), and potassium carbonate (13.8 g, 100 mmol) in DMF (150 ml) was heated to 50° C. overnight. After dilution with water the product was filtered off. Recrystallization from water/ethanol 1:2 gave pure product. Yield 5.6 g (46%) mp 196°-197° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05314903 |
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| Source dataset | uspto-grants-1994_05 |
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| ORD ID | ord-b8e4be9f9b5e41f6b766a8fd9af51a3b |
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| Source note | uspto-grants-1994_05 |
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