HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → Ethyl 4,5-dioxo-1-phenyl-3-pyrrolidineacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | 1-Phenylpyrrolidine-2,3-dione | HCID 19023571 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl 4,5-dioxo-1-phenyl-3-pyrrolidineacetate | HCID 57059855 | — |
Reaction Steps
A solution of the product of Example 61 in THF is added to a solution of lithium di-iso-propylamide (LDA) in THF at -78° C. After 2 h at -78° C. a solution of ethyl bromoacetate is added and the reaction is allowed to warm to room temperature. After an aqueous workup the crude product is chromatographed on silica gel to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05314886 |
| Source dataset | uspto-grants-1994_05 |
| ORD ID | ord-9614d5b86732459194f1a2cfec8b8256 |
| Source note | uspto-grants-1994_05 |