Aniline → HCID 41532166, compound

Participants

Reaction Steps

Utilising a modification of the procedure described in Example 8 employing 4 equivalents of trimethylaluminium and 4 equivalents of aniline (0.67 g, 7.2 mmol) in lieu of benzylamine with respect to 1 equivalent of ethyl 4-(1H-benzimidazylmethyl)benzoate yielded a crude product was purified by column chromatography (flash silica gel, gradient elution 0-100% ethyl acetate in hexane) and recrystallised from methanol to give N-phenyl 4-(1H-benzimidazylmethyl)benzamide (75 mg, 13%) as a white crystalline solid.

Provenance & Evidence