Hydrogen Peroxide → 5-Phenyl-2-picoline N-oxide

참여 물질

반응 조건

반응 단계

To a solution of 100 g 5-phenyl-2-picoline in 170 mL of glacial HOAc was added 30% H2O2 and the resulting solution was heated at 70° C. overnight. After the reaction mixture was cooled to room temperature, 1 g of 10% Pd/C was added to destroy any excess of H2O2. The reaction mixture was then filtered on celite, washed with toluene, and the filtrate was evaporated to dryness affording a yellow solid residue. The crude material was swished with a mixture of Et2O/EtOAc (10:1) and filtered to afford the pure title product as a white solid, m.p.: 91° C.

출처 및 근거