HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 3-(2,4,6-Triiodophenoxy)nonane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,4,6-Triiodophenol | HCID 11862 | — |
| Reactant | 3-Nonanol | HCID 12216 | — |
| Reactant | Methanesulfonate | HCID 85257 | — |
| Reactant | 2-(2,4,6-Triiodophenoxy)pentadecane | HCID 15343309 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(2,4,6-Triiodophenoxy)nonane | HCID 19959848 | 67.3% |
Reaction Steps
The mesylate of 3-nonanol (11.5 g, 51.9 mmol), triiodophenol (24.5 g, 51.9 mmol) and potassium carbonate (7.18 g, 51.9 mmol) were reacted in dry DMF (200 ml) as per 2-(2,4,6-triiodophenoxy)-pentadecane except at an oil bath temperature of 87° C. for 16 hrs. The reaction was processed as for 2-(2,4,6-triiodophenoxy)-pentadecane to provide a light brown oil. Flash column chromatography (silica, hexanes) provided 3-(2,4,6-Triiodophenoxy)-nonane (20.9 g, 67%) as a clear viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05316755 |
| Source dataset | uspto-grants-1994_05 |
| ORD ID | ord-01e4a383975d4ce6a7d6350797ae6345 |
| Source note | uspto-grants-1994_05 |