HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → HCID 22851825, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Isobutylene | HCID 8255 | — |
| Reactant | HCID 22851824 | HCID 22851824 | — |
| Product | HCID 22851825 | HCID 22851825 | — |
Reaction Steps
Reaction of isobutylene with N-chlorosulfonylisocyanate 57 in diethyl ether gives the azetidinone derivative 58. Removal of the chlorosulfonyl group with aqueous sodium sulfite followed by reaction with di-t-butyl-dicarbonate gives the BOC-protected intermediate 60. Alkaline hydrolysis gives the protected amino acid derivative 61 in good overall yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05317017 |
| Source dataset | uspto-grants-1994_05 |
| ORD ID | ord-f384fcf1d6b344c19aab290be3bf04b4 |
| Source note | uspto-grants-1994_05 |